Title: Effect of Shuxuetong TNF-a in rats cerebral ischemia reperfusion
Abstract: Objective Shuxuetong was evaluated its protective effects through observing expression of TNF-a.Methods 42 wistor rats were randomly divided into 3 groups,sham operation group,saline control group and Shuxuetong treatment group.Saline control group and Shuxuetong treatment group were divided into 3 h、 6 h、24 h.The left middle cerebral artery ischemia-reperfusion injury model(MCAO) was made by Koizumi suture-occluded method.The content of tumor necrosis factor-a(TNF-a)in serum and brain,were evaluated with immunohistochemical method.Results The expression of TNF-a of cerebral ischemia-reperfusion:There was almost no expression of TNF-a in sham operation group.The expression of TNF-a in saline control group increased in 3 h and reached peak in 6 hours and then gradually decreased.Compared with that in saline control group,the expression of TNF-a in Shuxuetong treatment group obviously reduced(P0.05).Conclusion Shuxuetong could reduce the expression of TNF-a and protect the brain.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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