Title: Detection of the differential expression of genes associated with apoptosis in the drug resistant ALL patiens with cDNA microarray
Abstract: [Objective] To explore the molecular pathological mechanism of multidrug resistance by detecting the differential expression of apoptosis associated genes between the multidrug resistant/non-resistant acute lymphocytic leukaemia(ALL) patiens.[Method] Omni-RNA was extracted with TRIzol from peripheral blood and reversely transcribed to cDNAs as hybridization probes which were hybridized with BioStar 4 096 cDNA microarray.Then the differentially expressed genes related to apoptosis between the two groups were analyzed.[Results] 150 genes expressed differently including 83 lower expression and 67 higher expression genes in multdrug resistant patiens group.Among the 150 genes,6 genes associated with apoptosis were up-regulated and 8 genes were down-regulated.[Conclusion] Genes associated with apoptosis were abnormally expressed may be one of molecular pathological mechanism of the multidrug resistant.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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