Title: Mechanism to Prevent genetic hypertension by early captopriltreatment in spontaneously hypertensive rats 1
Abstract: The mechanism of early captopril (Cap)treatment to prevent hypertension was explored. Cap(100 mg· kg-1· d-1) was administered orally tospontaneously hypertensive rats (SHR) from intrauterine pe-riod to 16 wk of age. Experiments were performed at 40 wkof age. Systolic blood pressure (fSBP) was measured.Vaseular medium and lumen ratio (M / L) was determinedby morphometric method. Functions of vascular contractionand relaxation were studied using hindquarter perfusion ofFolkow's model and aortic ring segment experiment in vitrorespectively. Early-onset Cap therapy significantly de-creased SBP. After discontinuance of treatment for 24 wk.SBP of Cap treated SHR (SHRcap) was still maintained atlower level than that of untreated SHR (21. 1±1. 1 vs 28.5 ±1.1 kpa, P0.001). The M/L in various vesscls waspronouncedly reduced in the treated group and was almostidentical to the level of WistarKyoto (WKY) rats.Vasorelaxation sensitivity and maximum relaxation to so-dium nitroprusside in SHRcap thoracic aortas were morepronounced while compared with those in SHR. Hindquart-er perfusion with phenylephrine showed that minimum andmaximum perfusion pressure, maximum slope weresignificantly higher in SHR than in WKY rats. and therewas a lower EC50 in SHR than in WKY rats. No signifi-cant difference in above four indexes was found betweenSHRcap and WKY rats. Conclusion early treatment withCap in SHR prevented the development of hypertension.The effect of Cap to reduce blood pressure persistently afterwithdrawal of treatment might result frorn reducingperipheral vascular resistance and improving vasomotorfunction on the basis of inhibiting vascular hypertrophy per-manently.
Publication Year: 1995
Publication Date: 1995-01-01
Language: en
Type: article
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