Title: Protective effect of nitrendipine and captopril on the renal vessel function in spontaneous hypertensive rats
Abstract: Abstract AIM: To compare protective effect of nitrendipine with that of captopril on the renal vessel function in spontaneous hypertensive rats. METHODS: SHRs and Wistar-Kyoto (WKY) rats of 14 week old were used in this study. All animals were divided into six groups ( n =6, each respectly). (1) WKY14 group and (2) SHR14 group, (3) SHRs treated with nitrednipine (30mg·kg -1 /d) for 14 weeks (SHR Ni28).(4) SHR treated with captopril (50mg·kg -1 /d) for 14 weeks (SHRcp28). (5) SHRs without treatment (SHR28). (6) WKY rats of 28 week old (WKY28). An isolated perfused kindey with constant flow volume was used to observe the renal vasocontractive reaction by norepine phrine (NE) and tarium chloride. RESULTS: Supernormal vasocontractive reaction was found in SHR14 and stronger reaction in SHR28 as comparison with the age-matched WKY rats. While 14 week SHR groups were treated with nitrendipine or captopril for 14 weeks, the renal vasocontractive reaction weakened obviously and the tension was similar to that of WKY. CONCLUSION: Nitrendipine and captopril treatment regressed the renal vasocontractive malfunction in SHR and their protective effects were similar at a similar antihypertensive extent. MeSH Hypertension;Renal artery;Nitrendipine;Captopril;Rats
Publication Year: 1998
Publication Date: 1998-01-01
Language: en
Type: article
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