Title: Pharmacokinetics of azithromycin tablet after a single oral dose in Chinese healthy volunteers
Abstract: Objective To study the pharmacokinetics of azithromycin tablet in Chinese healthy volunteers. Methods Ten healthy volunteers were given a single oral dose of 500 mg azithromycin tablet. The serum concentrations of azithromycin were determined by HPLC - UV. The compartment model was fitted by AIC - F test method The pharmacoki-netic parameters were calculated by DAS program. Results The main pharmacokinetic parameters of azithromycin for orally administered tablet were as follows: Ka was (0.87 ±0.27)h-1 ,t1/2β was (39.66 ± 10. 85) h,tmax was (2.60 ±0.52) h,Cmax was (451. 19 ±67.72) μg · L-1 ,CL/ F was (0.56±0.13)L · (h · kg)-1 ,AUC0-144 was (13.68 ±2.92) mg · h ·L-1 and AUC0-β was (13.71 ±2.91) mg · h · L-1. Conclusion The pharmacokinetics was best fitted to a two - compartment model.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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