Title: Melatonin decreases expression of transforming growth factor-β_1 in renal cortex of diabetic rats
Abstract: Transforming growth factor-β_1 (TGF-β_) mRNA or protein expression in renal cortex of diabetic rats was assessed by real-time quantitative RT-PCR with SYBR Green,immunohistochemistry or Western blot.After melatonin treatment,the expressions of TGF-β_1 mRNA and protein were decreased,suggesting that beneficial effect of melatonin may result from its antioxidative property and inhibiting TGF-β_1 expressions.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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