Title: Expression of Transforming Growth Factor-β_1mRNA in the Kidneys of Active Heymann Nephritis
Abstract: Objective The experiment was designed to explore the expression of transforming growth factor? β 1 (TGF? β 1)mRNA in the kidneys during different periods of active Heymann nephritis.Methods After successful induction of active Heymann nephritis in SD rats,the expression of TGF? β 1?mRNA was measured at week 4,6,8 and 12 after onset of AHN rats kidneys by reverse transcription polymerase chain reaction (RT?PCR) analysis.Result An up?regulation of TGF? β 1?mRNA was exhibited in the kidneys of AHN rats at week 4 after induction of the disease. The expression of TGF? β 1 mRNA reached a peak at week 8 and slightly down?regulated at week 12.Conclusion The expression of TGF? β 1 mRNA was up?regulated in AHN rats kidneys.TGF? β 1 may mediate the pathogenesis and development of active Heymann nephritis.
Publication Year: 2000
Publication Date: 2000-01-01
Language: en
Type: article
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