Title: Renal transplantation with or without dialysis in uremic patients: a comparison of clinical outcomes
Abstract: Objective:To compare the clinical outcomes of renal transplantation with or without dialysis in uremic patients,in an effort to assess the feasibility of renal transplantation without dialysis.Methods:The clinical data of 128 uremic patients who received renal transplantation without dialysis during Jan.2001 and Jul.2004(non-dialysis group) were retrospectively analyzed and compared with those of 569 patients who received renal transplantation with dialysis(dialysis group) during the same period.Results:The pre-transplantation hepatitis rate was 4.69% in nondialysis group and 18.45% in dialysis group(P(0.05).) After transplantation,the time for plasma creatinine returning to normal level was(7.26±5.49) d in non-dialysis group and(8.379±4.76) d in the dialysis group(P0.05).One month after transplantation,the levels of hemoglobin were((96.67±23.54) g/L) and(92.17±21.83) g/L in non-dialysis and dialysis group,respectively(P0.05);and the levels of albumin were(40.28±8.53) g/L and(38.34±7.84) g/L,respectively(P0.05).The acute rejection rates in non-dialysis group was significantly lower than that of dialysis group(19.53% vs 34.27%,P0.05);the infectious rate in non-dialysis and dialysis group were 28.13% and 36.38%,respectively(P0.05).The 1 year survival rates of patient/graft were 98.44% in non-dialysis and(97.72%/)95.96% in dialysis group(no significance);the 3 year survival rates of patient/graft were 96.23% in nondialysis and(94.4%/88%) in dialysis group(no significance).Conclusion:Renal transplantation without dialysis can avoid the dialysis complications and transfusion-induced sensitization,and reduce the risk of hepatitis infection as well as the acute rejection rate;while its patient/graft survival rate is similar to that of dialysis renal transplantation,making it feasible for clinical application.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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