Title: The clinical feasibility study on kidney transplantation for uremia patients without prior dialysis
Abstract: Objective To evaluate the feasibility and advantages of kidney transplantation for uremic patients without prior dialysis. Methods The clinical data of 146 uremic patients who presented for kidney transplantation without prior dialysis were retrospectively analyzed and compared with those of 653 dialysis patients undergoing kidney transplantation. Results The incidence of hepatitis was 5. 48 % in the nonuse dialysis group and 19. 14 % in the dialysis group prior transplantation with the difference being significant. After transplantation, there was no significant difference in the time of plasma creatinine returning to normal level between the nonuse dialysis group and the dialysis group. One month after transplantation, the levels of hemoglobin and albumin in the nonuse dialysis group were not significantly different from those in the dialysis group. The acute rejection rate, DGF and hepatic function impairment rate were 19.18 %, 6. 16 %, 9.59 % in nonuse dialysis group, while 33.54 %, 13.02 %, 25.57 % in dialysis group respectively, with the difference being significant. There were no significant differences in infectious rate and hypertension rate between the two groups. The patient/graft 1-year survival rate in the nonuse dialysis group and the dialysis group was 98. 63 % and 97. 24 % respectively, and the patient/graft 3-year survival rate was 95. 95 % and 89. 20 % , respectively (all P0. 05). Conclusions The kidney transplantation without prior dialysis offered comparable patient/graft survival to kidney transplantation with prior dialysis and avoided the dialysis complications and sensitization of transfusion, while reduced the risk of acute rejection. Therefore, uremic patients may be considered to receive the kidney transplantation without prior dialysis in clinic.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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