Title: The Effect of Huanglian Wendan Decoction on Inflammatory Factors and VCAM-1 of Metabolic Syndrome Rats
Abstract: Objective:To study the effects of Huanglian Wendan decoction on inflammatory factors and VCAM-1 of rats with metabolic syndrome induced by dietary,and analyse the mechanism.Method: Male SD rats were fed by high energetic diet for 20 weeks to copy the model of metabolic syndrome.37 model rats with metabolic syndrome were randomly divided into 4 groups: model group,herb high-dose group,herb low-dose group and control group,and each group was lavaged with drugs for 4 weeks to detect H-E staining of aorta,inflammatory factors and VCAM-1.Result: Compared with the normal group,the level of IL-6 and ADPN in model group had a statistical significance(P0.05).Contrast to model group,the serum level of IL-6 and ADPN in herb high-dose group,low-dose group and control group had a statistical significance(P0.05).The expression of VCAM-1 of rats in herb high-dose group,low-dose group and control group decreased obviously which had a statistical significance(P0.05).Conclusion:Huanglian Wendan decoction can regulate the serum level of IL-6 and ADPN and repress the over-expression of VCAM-1.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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