Title: The detection of S-100 protein and its clinical significance in patients with systemic lupus erythematosus
Abstract: Objective: To investigate the relationship between serum S-100 protein and systemic lupus erythematosus (SLE). Methods: Serum levels of S-100 protein were examined in SLE patients using an enzyme-linked immunosorbent assay (ELISA). Patients were grouped as inactive SLE (ISLE) (n = 6), active SLE without unequivocal neurologic manifestation (ASLE) (n = 20), or active SLE with unequivocal neurologic or psychiatric manifestation (NPSLE) (n = 5). As control 10 healthy people were also recruited. Results: The levels of serum S-100 protein were higher in all SLE groups than that in control group (P 0.05). Among these three SLE groups, it was significantly higher in the NPSLE group (P 0.01). Conclusions: This result presents a significant correlation between the SLE patients and serum S-100 protein. High levels of serum S-100 protein may indicate the neuropsychiatric damage of SLE.
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot