Title: Effects of Simvastatin and Fluvastatin on the plasma levels of C-reactive protein in patient with coronary heart disease
Abstract: AIM: To explore the effects of Simvastatin and Fluvastatin on the plasma levels of C reactive protein (CRP) in patient with coronary heart disease(CHD). METHODS: 156 CHD patients were randomly divided into three groups:Group A treated with placebo,Group B with simvastatin and Group C with fluvastatin,and their plasma CRP and total cholesterol(TC) levels were measured by nephelometry before and 4,6 and 8 weeks after the treatment. RESULTS: ①4,6 and 8 weeks after the treatment,the plasma CRP levels of Groups B and C were significantly lower than those of Group A(P0.05,P0.01 and P0.01 respectively). ②Both B group and C goup were treated after 4 weeks,6 weeks,8 weeks,their plasma levels of CRP were significantly lower than that before treated(respectively P0.05,P0.01,P0.01). ③In Groups B and C,the plasma TC levels were markedly lower 4,6 and 8 weeks after the treatment than before the treatment (P0.05,P0.05 and P0.01 respectively). ④There was no correlation between the decrease of CRP levels and that of TC levels in Groups B and C(P0.05). CONCLUSION: Lipid lowering therapy with simvastatin and fluvastatin have beneficial effects on antiinflammation.
Publication Year: 2002
Publication Date: 2002-01-01
Language: en
Type: article
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