Title: The Action of Bone Marrow Mononuclearcell Transplantation on Alcoholic Liver Fibrosis in Mice
Abstract: Objective To explore the action of bone marrow mononuclearcell transplantation on hepatic fibrosis in mice.Method 16 female mice with alcoholic liver fibrosis were randomly divided into group A(n = 8) and B(n =8).The mice in group A received syngeneic male mice bone marrow mononuclearcell transplantation.The animals in group B received isovolumetric IMDM supplemented with 10% new bovine serum infusion.The examinations of hepatic function,hepatic histopathology and collagen content in hepatic tissue were performed at the 30th day postoperatively.Result The hepatic function and morphosis restoration in group A were significantly better than those in group B.The collagen content in liver in group A was markedly less than that in group B.Conclusion The function and structure of the fibrotic liver could be ameliorated and the collagen content in liver could be reduced significantly by bone marrow mononuclearcell transplantation in mice.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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