Title: Effects of dexmedetomidine on the change of S100β protein and neuron specific enolase level during cardiopulmonary bypass in cardiac valve replacement surgery
Abstract: Objective To evaluate the effects of dexmedetomidine on the change of S100β protein and neuron specific enolase (NSE) level during cardiopulmonary bypass (CPB) in cardiac valve replacement surgery.Methods Thirty patients scheduled for cardiac valve replacement were randomly divided into two groups. Dexmedetomidine at the dose of 0.2 μg·kg-1·h-1 and the same volume of saline was infused intravenously after induction of anesthesia in the group D and group C respectively. Blood samples were taken from internal jugular vein in each of the following five time points: after induction of anesthesia(T1),at rewarming(T2),aortic declamping(T3),after the termination of CPB 6 h(T4) and 24 h (T5) for determination of S100β protein and NSE by ELISA.Results Plasma S100β protein and NSE rose significantly at the time of T2-T4 than that at T1 in both groups (P0.01). At the time of T5 all plasma returned to preoperative levels in both groups. The concentration of S100β protein and NSE levels in group D were significantly lower than those in group C (P0.01) at the time of T2-T4.Conclusion Dexmedetomidine can reduce the release of the S100β protein and NSE and alleviate the brain injury resulting from cardiopulmonary bypass in cardiac valve replacement surgery.
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
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