Title: Analysis of characteristics and risk factors of lower respiratory infections in patients with acute leukaemia
Abstract: OBJECTIVE To explore characteristics of composition and drug resistance of pathogens and analyze the risk factors of lower respiratory tract infections in the acute leukaemia patients so as to guide the clinical treatment.METHODS A total of 40 patients with lower respiratory tract infections were selected from 87 patients with acute leukaemia.The sputum specimens were collected and processed by bacterial culture and drug susceptibility testing.The risk factors were analyzed by logistic regression analysis.RESULTS Of the pathogens causing lower respiratory tract infections in 40 patients,the gram-negative bacteria accounted for 67.21%,the gram-positive bacteria 24.59%,fungi 8.20%;the predominant species were Klebsiella pneumoniae,Escherichia coli,Staphylococcus aureus,Pseudomonas aeruginosa,and Acinetobacter baumannii;the result of drug susceptibility testing showed that the pathogens were multidrug-resistant,the drug resistance rates of the K.pneumoniae to imipenem and meropenem were 18.75% and 12.50%,respectively,the drug resistance rates of the S.aureus to vancomycin and teicoplanin were 0;the drug resistance rate of the Candida albicans to amphotericin B was 0.The study concluded that the Hb≤50 g/L,Pt count ≤30×109/L,prophylactic use of antibiotics and use of glucocorticoid were identified as risk factors of lower respiratory tract infections in patients with acute leukaemia.CONCLUSION The interventions to risk factors could be helpful,and sensitive antibiotics should be chosen for the treatment of lower respiratory tract infections in patients with acute leukaemia.
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
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