Title: Effect of angiotensin II on the syntheses of DNA, RNA and collagen protein in isolated fibroblasts from myocardium-infarcted rats
Abstract: AIM and METHOD: Isotope-labelled substrate incorporation method was used to investigate the effect of angiotensin Ⅱ(Ang Ⅱ) on the syntheses of DNA, RNA and collagen protein of isolated fibroblasts(Fbs) from myocardial infarction (MI) and sham operated (SO) rats in different conditions. RESULTS: The incorporating rates of 3H-thymidine, 14 C-uridine and 3H-proline of Fbs from MI group were significantly higher than that of SO group, respectively. These effects of Ang Ⅱ on Fbs were abolished completely either by angiotensin antagonists, 1 8 Ang Ⅱ, or by angiotensin antipeptide. On the other hand,angiotensin receptor antagonist, losartan, can not thoroughly eliminate the above-mentioned effects of Ang Ⅱ. CONCLUSIONS: (1) Ang Ⅱ promoted the syntheses of DNA, RNA and collagen protein in Fbs; (2) The responsiveness of Fbs to Ang Ⅱ from MI rats was higher than that of normal rats; (3)AT 1 receptor is not the only substype which regulates the action of Ang Ⅱ to Fbs metabolism.
Publication Year: 1999
Publication Date: 1999-01-01
Language: en
Type: article
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