Title: The renoprotective effect of fosinopril and its effect on TGFβ_1 mRNA expression in renal tissue in diabetic rats
Abstract:Objective To observe the renoprotective effects of angiotensin converting inhibitor(ACEI)-fosinopril and explore its renoprotective mechanism among diabetic rats.Methods Normal control rats(group A);d...Objective To observe the renoprotective effects of angiotensin converting inhibitor(ACEI)-fosinopril and explore its renoprotective mechanism among diabetic rats.Methods Normal control rats(group A);diabetic rats(group B),fosinopril rats(group C) were studied.Blood glucose,urinary albumin and retinal-binding protein(RBP) excretion rates were measured at the 1st,2nd,4th and 12th week,as well as the expressions of TGFβ_(1) mRNA in renal cortex and the relative kidney index(ratio between kidney weight and body weight) at the 4th and 12th week.Renal pathplogy of diabetic rats was observed at the 4th and 12th week.Results At the 1st week(no treatment given),the urinary excretion rates of albumin in group B and C were similar to that in group A.At the 2nd,4th and 12th week,the urinary excretion rates of albumin and RBP in group B were higher than that in group A. The expression of TGF-β,mRNA inrenal cortex in group C was significantly lower than that in group B;the expression of TGFβ_(1) mRNA in renal cortex in group B was much higher than that in group A;the electron microscopy showed significant mesangial expansion,glomerular basement membrane thickening in group B,but these abnormal changes were alleviated to a certain extent in group C.Conclusions The overexpression of TGFβ_(1) mRNA in renal cortex of diabetic rats may be one of the mechanisms of diabetic nephropathy;fosinopril had certain renoprotective effects.Read More
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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