Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2411797960', 'doi': None, 'title': '[Influence of irbesartan on renal hypertrophy and thickening of glomerular basement-membrane in streptozotocin-induced diabetic rats].', 'display_name': '[Influence of irbesartan on renal hypertrophy and thickening of glomerular basement-membrane in streptozotocin-induced diabetic rats].', 'publication_year': 2003, 'publication_date': '2003-05-01', 'ids': {'openalex': 'https://openalex.org/W2411797960', 'mag': '2411797960', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12882713'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/12882713', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5058396165', 'display_name': 'Bi‐Cheng Liu', 'orcid': 'https://orcid.org/0000-0002-4584-1853'}, 'institutions': [{'id': 'https://openalex.org/I4210105806', 'display_name': 'Zhongda Hospital Southeast University', 'ror': 'https://ror.org/01k3hq685', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210105806']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Bi-cheng Liu', 'raw_affiliation_strings': ['Renal Division, Zhong Da Hospital, Southeast University School of Medicine, Nanjing 210009, China.'], 'affiliations': [{'raw_affiliation_string': 'Renal Division, Zhong Da Hospital, Southeast University School of Medicine, Nanjing 210009, China.', 'institution_ids': ['https://openalex.org/I4210105806']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032713477', 'display_name': 'Dong-Dong Luo', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Dong-dong Luo', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047601323', 'display_name': 'Jing Sun', 'orcid': 'https://orcid.org/0000-0002-2454-5553'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Jing Sun', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103715560', 'display_name': 'Kun‐Ling Ma', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Kun-ling Ma', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5109221297', 'display_name': 'Xiongzhong Ruan', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Xiong-zhong Ruan', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.227, 'has_fulltext': False, 'cited_by_count': 4, 'citation_normalized_percentile': {'value': 0.436438, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 72, 'max': 74}, 'biblio': {'volume': '42', 'issue': '5', 'first_page': '320', 'last_page': '3'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T13223', 'display_name': 'Connective Tissue Growth Factor Research', 'score': 0.9224, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T13223', 'display_name': 'Connective Tissue Growth Factor Research', 'score': 0.9224, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/irbesartan', 'display_name': 'Irbesartan', 'score': 0.7513037}, {'id': 'https://openalex.org/keywords/renal-hypertrophy', 'display_name': 'Renal Hypertrophy', 'score': 0.42787266}, {'id': 'https://openalex.org/keywords/glomerulosclerosis', 'display_name': 'Glomerulosclerosis', 'score': 0.4164573}], 'concepts': [{'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.83421934}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.8277283}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.81783676}, {'id': 'https://openalex.org/C2779922275', 'wikidata': 'https://www.wikidata.org/wiki/Q1129105', 'display_name': 'Diabetic nephropathy', 'level': 3, 'score': 0.77988696}, {'id': 'https://openalex.org/C2780259554', 'wikidata': 'https://www.wikidata.org/wiki/Q947266', 'display_name': 'Irbesartan', 'level': 3, 'score': 0.7513037}, {'id': 'https://openalex.org/C2779280383', 'wikidata': 'https://www.wikidata.org/wiki/Q257331', 'display_name': 'Streptozotocin', 'level': 3, 'score': 0.657774}, {'id': 'https://openalex.org/C2776115139', 'wikidata': 'https://www.wikidata.org/wiki/Q1753456', 'display_name': 'Glomerular basement membrane', 'level': 4, 'score': 0.5635377}, {'id': 'https://openalex.org/C555293320', 'wikidata': 'https://www.wikidata.org/wiki/Q12206', 'display_name': 'Diabetes mellitus', 'level': 2, 'score': 0.4897821}, {'id': 'https://openalex.org/C2780091579', 'wikidata': 'https://www.wikidata.org/wiki/Q9377', 'display_name': 'Kidney', 'level': 2, 'score': 0.4799519}, {'id': 'https://openalex.org/C159641895', 'wikidata': 'https://www.wikidata.org/wiki/Q108377937', 'display_name': 'Renal function', 'level': 2, 'score': 0.473618}, {'id': 'https://openalex.org/C2779561371', 'wikidata': 'https://www.wikidata.org/wiki/Q570197', 'display_name': 'Proteinuria', 'level': 3, 'score': 0.45840767}, {'id': 'https://openalex.org/C2909763481', 'wikidata': 'https://www.wikidata.org/wiki/Q1054718', 'display_name': 'Renal Hypertrophy', 'level': 4, 'score': 0.42787266}, {'id': 'https://openalex.org/C2780631158', 'wikidata': 'https://www.wikidata.org/wiki/Q14907752', 'display_name': 'CTGF', 'level': 4, 'score': 0.42745203}, {'id': 'https://openalex.org/C2780306776', 'wikidata': 'https://www.wikidata.org/wiki/Q426660', 'display_name': 'Creatinine', 'level': 2, 'score': 0.42223614}, {'id': 'https://openalex.org/C2777390665', 'wikidata': 'https://www.wikidata.org/wiki/Q5571239', 'display_name': 'Glomerulosclerosis', 'level': 4, 'score': 0.4164573}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.20525748}, {'id': 'https://openalex.org/C2775960820', 'wikidata': 'https://www.wikidata.org/wiki/Q408378', 'display_name': 'Growth factor', 'level': 3, 'score': 0.14017108}, {'id': 'https://openalex.org/C84393581', 'wikidata': 'https://www.wikidata.org/wiki/Q82642', 'display_name': 'Blood pressure', 'level': 2, 'score': 0.11737487}], 'mesh': [{'descriptor_ui': 'D047228', 'descriptor_name': 'Angiotensin II Type 1 Receptor Blockers', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D001713', 'descriptor_name': 'Biphenyl Compounds', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D003921', 'descriptor_name': 'Diabetes Mellitus, Experimental', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D003928', 'descriptor_name': 'Diabetic Nephropathies', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D007668', 'descriptor_name': 'Kidney', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D007678', 'descriptor_name': 'Kidney Glomerulus', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D013777', 'descriptor_name': 'Tetrazoles', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D047228', 'descriptor_name': 'Angiotensin II Type 1 Receptor Blockers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001485', 'descriptor_name': 'Basement Membrane', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001485', 'descriptor_name': 'Basement Membrane', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D001713', 'descriptor_name': 'Biphenyl Compounds', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003921', 'descriptor_name': 'Diabetes Mellitus, Experimental', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003928', 'descriptor_name': 'Diabetic Nephropathies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006984', 'descriptor_name': 'Hypertrophy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077405', 'descriptor_name': 'Irbesartan', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007668', 'descriptor_name': 'Kidney', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007678', 'descriptor_name': 'Kidney Glomerulus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011897', 'descriptor_name': 'Random Allocation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017207', 'descriptor_name': 'Rats, Sprague-Dawley', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013777', 'descriptor_name': 'Tetrazoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/12882713', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.74, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3196913869', 'https://openalex.org/W2411797960', 'https://openalex.org/W2375587156', 'https://openalex.org/W2348277819', 'https://openalex.org/W2167848404', 'https://openalex.org/W2156575418', 'https://openalex.org/W2134335719', 'https://openalex.org/W2101097479', 'https://openalex.org/W2096973883', 'https://openalex.org/W2044283979'], 'abstract_inverted_index': {'To': [0], 'investigate': [1], 'the': [2, 89, 129, 169, 177, 195, 224, 256, 265, 278], 'influence': [3], 'of': [4, 16, 65, 104, 121, 135, 154, 171, 179, 197, 226, 258, 272, 296, 302], 'angiotensin': [5], 'II': [6], 'receptor': [7], 'antagonist': [8], 'irbesartan': [9], '(Irb)': [10], 'on': [11], 'renal': [12, 108, 287, 297, 300], 'hypertrophy': [13, 106, 298], 'and': [14, 49, 119, 141, 159, 174, 176, 202, 246, 270, 299], 'thickening': [15, 225], 'glomerular': [17, 113, 116, 266], 'basement': [18], 'membrane': [19], '(GBM)': [20], 'in': [21, 88, 181, 205, 290], 'streptozotocin': [22], '(STZ)': [23], 'induced': [24, 62], 'diabetic': [25, 42, 50, 182, 206, 291], 'rats.Sprague-Dalwley': [26], '(SD)': [27], 'rats': [28, 69, 90, 130, 183, 207], 'were': [29, 86, 123, 131, 146], 'randomly': [30], 'divided': [31], 'into': [32], 'three': [33], 'groups:': [34], 'normal': [35], 'control': [36], '(group': [37, 44, 55], 'N,': [38], 'n': [39, 46, 57], '=': [40, 47, 58], '7),': [41], 'nephropathy': [43, 51], 'DN,': [45], '6)': [48], 'treated': [52], 'with': [53, 264], 'Irb': [54, 165, 192, 221, 284], 'DNI,': [56], '7).': [59], 'Diabetes': [60], 'was': [61], 'by': [63, 148], 'injection': [64], 'STZ': [66], 'intraperitoneally': [67], 'after': [68], 'had': [70], 'received': [71], 'uninephroectomy.': [72], 'Blood': [73], 'glucose': [74], '(BG),': [75], 'body': [76], 'weight': [77, 101], '(BW),': [78], 'urinary': [79], 'albumin': [80], 'excretion': [81, 173], '(Ualb),': [82], '24-hour': [83], 'proteinuria': [84], '(24hUpro)': [85], 'observed': [87], 'at': [91, 125], 'week': [92, 126], '4,': [93], '8,': [94], '12': [95, 127], 'respectively.': [96], 'Creatinine': [97], 'clearance': [98], '(Ccr),': [99], 'kidney': [100, 105], '(KW),': [102], 'profile': [103], '(KW/BW),': [107], 'tissue': [109, 137], 'protein': [110], 'contents': [111], '(RTP),': [112], 'area': [114], '(A(G)),': [115], 'volume': [117], '(V(G)),': [118], 'width': [120], 'GBM': [122, 227], 'determined': [124, 147], 'when': [128], 'sacrificed.': [132], 'Renal': [133], 'expression': [134, 260, 301], 'connective': [136], 'growth': [138, 143], 'factor': [139], '(CTGF)': [140], 'transforming': [142], 'factor-beta(1)': [144], '(TGF-beta(1))': [145], 'immunohistochemistry.There': [149], 'is': [150, 261, 277], 'no': [151], 'significant': [152], 'difference': [153], 'BG': [155], 'between': [156], 'group': [157, 160], 'DN': [158, 234], 'DNI': [161, 240], '(P': [162, 184, 208, 250, 274], '>': [163], '0.05).': [164], 'treatment': [166], 'significantly': [167, 222], 'prevented': [168, 223], 'increase': [170], 'Ualb': [172], '24hUpro': [175], 'deterioration': [178], 'Ccr': [180], '<': [185, 188, 209, 212, 251, 275], '0.05,': [186, 210], 'P': [187, 211], '0.01': [189, 213], 'respectively).': [190, 214, 253], 'Furthermore,': [191], 'markedly': [193], 'inhibited': [194], 'increasing': [196], 'KW,': [198], 'KW/BW,': [199], 'RTP,': [200], 'AG': [201], 'VG': [203], 'shown': [204], 'More': [215], 'interestingly,': [216], 'we': [217], 'firstly': [218], 'demonstrated': [219], 'that': [220, 283], '[N': [228], 'group:': [229, 235, 241], '(127.50': [230], '+/-': [231, 237, 243], '22.14)': [232], 'nm,': [233, 239], '(280.38': [236], '52.77)': [238], '(144.07': [242], '24.85)': [244], 'nm]': [245], 'immunostaining': [247, 267], 'for': [248, 268], 'CTGF': [249, 259], '0.05': [252], 'In': [254], 'addition,': [255], 'extent': [257], 'positively': [262], 'correlated': [263], 'TGF-beta(1)': [269], 'size': [271], 'V(G)': [273], '0.01).This': [276], 'first': [279], 'data': [280], 'to': [281], 'demonstrate': [282], 'exerts': [285], 'early': [286], 'protective': [288], 'role': [289], 'nephropathy,': [292], 'possibly': [293], 'through': [294], 'inhibition': [295], 'CTGF.': [303]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2411797960', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}], 'updated_date': '2024-12-08T10:57:06.843698', 'created_date': '2016-06-24'}