Title: Coronary angiographic findings in patients with glucometabolic abnormality and coronary heart disease
Abstract: Objective To analyze the characteristics of coronary angiographic(CAG) findings in patients with glucometabolic abnormality and coronary heart disease(CAD).Methods A total of 130 patients with CAD confirmed by CAG were included in this study.The blood pressure,blood glucose,fasting insulin(FIns),serum lipid profile,and body mass index(BMI) of all patients were determined.According to the result of 75g OGTT,they were divided into 3 groups: normal glucose tolerance(NGT),impaired glucose tolerance(IGT),and diabetes mellitus(DM) respectively for comparing the characteristics of CAG findings.Results Compared with the NGT patients,the IGT and DM patients suffered from more multiple vessel lesions,severe coronary artery stenosis(77.5% and 78.4% vs 56.6%),diffuse lesions(40.0% and 40.5% vs 17%),the right coronary artery(RCA) lesions(67.5% and 64.9% vs 41.5%),and the cumulative scores [(5.275±1.768) and(5.865±2.720) vs(4.132±1.765)](P0.05 or P0.01).The 2 hour plasma glucose(2 hPG),insulin resistance index(HOMA-IR),waist-to-hip rate(WHR),apo-lipoprotein B(Apo-B),smoking,BMI,hypertension,family history of CAD were the independent factors of predicting CAD(P0.01).Conclusions The coronary artery lesions are getting worse with the progress of glucometabolic abnormality,and this phenomenon may present in the impaired glucose tolerance period.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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