Title: Electro-colposcopic and pathologic observation of subclinical human papillomavirus infection and cervical intraepithelial neoplasia
Abstract: Objective:To investigate the diagnostic value of electro-colposcope(EC) examination in patients with subclinical human papillomavirus (HPV) infection(SPI) and cervical intraepithelial neoplasia (CIN), and its concordance with pathologic diagnosis. Methods:Totally 1 420 females were examinaed with EC, and cervix biopsies and immunotistochemistry stainings for HPV-6,11,18 were performed in 209 of them. Results:EC images of SPI and CIN showed that there were a various of degrees of blanc epithelium stained acetic acid, abnormal blood vessel and iodine negative staining. Histologically, HPV infection was characterized by koilocytosis, and the lesion was found in most(62, 74.6%) patients with SPI and CIN. By light microscopic observation and immunotistochemistry technique, SPI was founded in 56 cases (20.79%), CINⅠ in 10 cases (4.78%), CINⅡ in 9 cases (4.31%), CINⅢ in 8 cases(3.83%) and chronic cervicitis in 126 cases (60.29%) . The positivie stain rate of HPV-6, 11, 18 was 23% (48/209) . The coincidence ratio of EC examination and pathological diagnosis was 88.04%(184/209, kappa value=0.755, P0.01). The sensitivity, specificity, positive predictive value and negative predictive value of EC examination for SPI and CIN were 90.36% (75/83), 86.51% (109/126), 81.52% (75/92) and 93.16% (109/117), respectively. There was no significant difference between the two examination methods (P0.05). Conclusion:It is suggested that EC is an effective and reliable diagnostic method for cervix lesions. Early diagnosis rates of SPI and CIN would be elevated by colposcopic biopsies of the cervix and combining with immunotistochemistry technique.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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