Title: Immunohistochemical study on expression of Cyclin D1 and Cyclin B1 in nasopharyngeal carcinoma
Abstract: Objective:To investigate Cyclin D1and Cyclin B1expression in nasopharyngeal carcinoma(NPC)and clinical significance,and analyze their relations.Methods:Cyclin D1and Cyclin B1expressions were assayed respectively in58nasopharyngeal carcinoma tissues by immunohistochemical method.Results:The positive expression rates of Cyclin D1and Cyclin B1in NPC were58.6%(34/58)and60.3%(35/58),respectively;The mean survival period,the five-year-survival rate and median survival period in Cyclin D1and Cyclin B1positive expression group were shorter than those in Cyclin D1and Cyclin B1negative ex-pression group(P0.05);The coincidence expression rate of Cyclin D1and Cyclin B1was60.3%(35/58)and no significant correlation existed between their expressions.Conclusions:Cyclin D1and Cyclin B1expressions may act as important predictors for NPC prognosis.
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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