Title: Application of ACCESS in screening of Down's syndrome in pregnant women at second trimesters
Abstract: Objective To explore the effect of the maternal serum markers of Alpha-fetoprotein (AFP),human chorionic go- nadotrophin(free beta-HCG)and u-Estriol(uE3)in screening of congenital fetal abnormality sucb as Down' s syndrome in the pregnant women at second trimester.Methods Serum samples were collected from 1310 pregnant women at second trimester,and AFP,β-HCG and uE3 were determined by all-automatic microparticle luminescence immunoassay(MLIA)in combination with other parameters of maternal age,weekof gestation,weight,whether or not twin pregnancy,diabetes etc.Amniotie fluid cell chromo- somes and ultrasonography were also conducted to those at high risk.Results The positive rate of Down's syndrome and trisomy 18 syndrome were 3.13% and 2.06% by ACCESS,but the risk rates of Down's syndrome and trisomy 18 syndrome were 5.42% and 2.90% by laboratory test.The positive rate of neural tube defects was 2.98% in the two groups.There 9 cases with congenital defects were detected from 1310 cases with a positive rate of 0.61%.Conclusion The joint screening of maternal serum markers of AFP,β-HCG and uE3 is a major way for preventing DS,NTD,trisomy 18 syndrome and other birth defects.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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