Title: Results of prenatal screening of 9368 cases with Down's syndrome in Maoming City
Abstract: Objective To understand prenatal conditions of screening of Down's syndrome in Maoming City. Methods The concentrations of serum markers, free beta-human chorionic gonadotropin(free β-HCG) and pregnancy associated plasma protein A(PAPP- A) were determined at early pregnancy by time differentiastion fluoroimmunoassay.At second frimester screening the levels of serum marker of AFP, concentration of T-β HCG, μE3 were determined by using chemiluminescence immunoassay analyzer and the results were analyzed in combination with parameters of age, weight, gestational age and other factors of pregnant women for risk assessment aided by supporting screening software. Those at risk were confirmed by chromosomal karyotypes, B ultrasound and amniotic fluid cytology analysis to prevent the birth of defect babies. Results Totally 9 368 pregnant women were screened for Down's syndrome, 403 women were positive for Down's syndrome with a positive rate of 4.30%, 6 Down's syndrome cases were confirmed by the chromosome test, 92 cases were at high risk for 18-trisomy with a positive rate of 0.98%. One Down's syndrome case was confirmed by karyotype analysis, 62 cases were at high risk for neural tube defects with the positive rate of 1.10% and finally 13 cases were confirmed with neural tube defects.Conclusion Prenatal screening and prenatal diagnosis of Down's syndrome is effective for reducing the defect birth rate and improving the eugenics and the quality of the population.
Publication Year: 2014
Publication Date: 2014-01-01
Language: en
Type: article
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