Title: Expressions of cell cycle-related proteins p16,p27 and invasive in pituitary adenoma
Abstract: Objective To study the relationship between the protein expressions of PCNA,p16, p27 and invasive in pituitary adenoma,to offer the experiment basis on effecting radical cure of pituitary adenomas and decreasing the recurring after surgery.Methods The expressions of protein were examined by immunohistochemical SP methods in 43 invasive pituitary adenomas and 37 non-invasive adenomas.To analyze the correlation of the abnormal expression of proteins p16,p27 and the proliferation cell nuclear antigen (PCNA) in pituitary adenomas.Results The expression of protein p16,p27 in invasive pituitary adenomas group were significantly lower than non-invasive group.There was no significant difference of the expression of protein p16 in recurring and non-recurring groups.The expression of protein p27 in recurring pituitary adenomas group were significantly lower than non-recurring group.Conclusions The abnormal protein expression of p16 and p27 may play roles in tumorigenesis and progression of pituitary adenoma,which can be taken as indicators to evaluae the tumor invasive potential and prognosis.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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