Title: Effect of doxazosin mesylate on plasma high-sensitivity C-reactive protein and nitric oxide in patients with essential hypertension
Abstract: Objective To investigate the effect of doxazosin on plasma levels of high-sensitivity C-reactive protein (hs-CRP) and nitric oxide (NO) in patients with essential hypertension. Methods The research population consisted of 40 normotensive control subjects and 40 patients with hypertension,and we measured plasma levels of hs-CRP and NO in normotensive subjects and in patients with hypertension before and after doxazosin therapy for 1 month. Results plasma hs-CRP levels were significantly higher (P 0.01) in patients untreated hypertensive group compared to controls. Significant decrease was observed for hs-CRP (P 0.05) in hypertensive patients after antihypertensive treatment. NO was significantly lower (P 0.01) in patients of the untreated hypertensive group compared to controls. Significant increase for NO (P 0.05) was observed in hypertensive patients after antihypertensive treatment. Conclusions These results suggest that doxazosin treatment exerts anti-inflammatory effects in addition to its antihypertensive properties in hypertensive patients.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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