Title: Efficacy observation of recombinant human interleukin-11 (I) in treatment of chemotherapy induced thrombocytopenia in patients with acute leukemia
Abstract: 【Objective】To observe the effectiveness and safety of recombinant human interleukin-11(Ⅰ) in the treatment of chemotherapy induced thrombocytopenia in patients with acute leukemia.【Methods】Sixty-eight patients with chemotherapy induced thrombocytopenia after intensive treatment of acute leukemia were divided into treatment group including thirty-five patients and control group including thirty-three patients.Patients in treatment group were given subcutaneous injection of recombinant human interleukin-11(Ⅰ) at the dose of 25 μg/kg.d.Drug withdrawal was conducted after platelet count being on two consecutive days than 50×10 9 /L or higher than 100×109/ L.Patients in control group were not use any elevating platelet drugs.【Results】In treatment group,the thrombocytopenia duration was shortened;the platelet transfusion volume was reduced;the platelet absolute value was higher than the control group.The difference was statistically significant.The main ADR were fatigue,headache,muscle pain,dropsy.【Conclusion】Recombinant human interleukin 11(Ⅰ) is effective in the treatment group of chemotherapy induced thrombocytopenia in patients with acute leukemia and its adverse reactions are slight.It is worth promoting.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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