Title: Synthesis of 7-[1-(2-tert.-butoxycarbonylaminothiazol-4-yl)-1(Z)-pentencarboxamido]-3-hydroxymethyl-3-cephem-4-carboxylic Acid
Abstract: A intermediate of Cefcapene 7-[1-(2-tert.-butoxycarbonylaminothiazol-4-yl)-1(Z)-pentencarboxamido]-3-hydroxymethyl-3-cephem-4-carboxylic acid in overall yield of 90.2% was synthesized by acidylation of 1-(2-tert.-butoxycarbonylaminothiazol-4-yl)-1(Z)-pentencarboxylic acid with methanesulphonyl chloride,then combination with hydroxymethyl-7-amino-cephalosporanic acid.The structure of product were confirmed 1H NMR,MS and IR.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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