Title: Synthesis and characterization of (S/R) -2-(2-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H) -yl) acetamido) propanoic acid
Abstract: (S)-and(R)-methyl 2-(2-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl) acetamido) propanoate enantiomer were synthesized by 5-flurouracil-1-yl acetic acid,L-and D-alanine methyl ester respectively,with N,N-diisopropylcarbodiimide(DIC) /1-Hydroxybenzotriazole(HOBt) as a coupling reagent,in which the yields were 82% and 80%,respectively.The corresponding acid enantiomer,with the yields of 80% and 81% respectively,were obtained after hydrolysis at room temperature.The structures of the compounds were characterized by 1H NMR,13C NMR,IR,MS,and the specific rotation etc.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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