Title: Analysis of Antibiotic Use in 480 In-patient Cases
Abstract: Objective To survey antibiotic use and its rationality in clinical settings.Methods Medical records of 480 in-patients between January and March of 2003 were randomly reviewed for retrospective studies.Analysis with regard to drug category,route,combination,purpose,duration,indication and resistance was conducted and solutions were proposed for the existing problems.Results The incidence of antibiotic use was 82%.45% of the cases were intended for active treatment,55% for preventive regimen.75% of the cases in internal medicine were for active treatment whereas 80% were surgical prophylaxis.The total number of antibiotics use was 635 cases.In terms of preventive use,single drug comprised 81%,two-drug 18% and three-drug 1%.As for active treatment,single drug consisted of 42%,two-drug 49% and three-drug 8% and four-drug 1%.The four leading injectable antibiotics included cephalosporines,penicillin,aminlglycosides and fluoroquinolones.Microbiological cultures were conducted in 39% of the cases with 40% being positive and fungus being the most common pathogen.Regarding rationality of antibiotic use,justified and partially justified cases comprised 61.9% while irrational cases made up 38.1%.Improrer routes and prolonged use of perioperative antibiotics were the dominant causes in those cases.Conclusion To improve antibiotic administration,systematic efforts are required to keep the medical staff updated of antibiotic principles and strengthen the ethics training in addition to furthering the health system reform.
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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