Title: The clinical observation of mifepristone treatment of 180 paitients with vterine fibroids
Abstract: Objective To observe the effect and different doses of mifepristone treatment of vterine fibroids.Methods 108 cases diagnosed of uterine flesh tumour patients into three groups,A group of 10 mg/d mifepristone influences the application,application of group B get 25 mg/d,application of group C 37.5 mg/d mifepristone influences.Menstruation day 1 beginning taking,and even served three months for a period of treatment.Before use,after B to exceed the womb and the measurement of uterine flesh tumour 3 d diameter line.Drug use 3 months before and after the determination of follicle-stimulating hormone (FSH),estradiol (E2),progesterone (P),corpus luteum erythropoietin (LH),liver and kidney function,routine blood test,observe the medicine adverse reactions.Results Three groups of patients during treatment are amenorrhoea,hemoglobin rise,three groups of uterine fibroid volume were significantly reduce and group A uterus down to 25.7% (P0.01),group B uterine down to 27.9% (P0.01),group C uterine down to 29.4% (P0.01).Group A maximum fibroid volume than before drug down to 28.8%(P0.05),the largest group B fibroid volume than before drug down to 29.9% (P0.01),the largest group C fibroid volume than before drug down to 32.6%(P0.01).Each group compared before and after treatment were significant difference(P0.01),FSH,E2,P,LH drug compared before and after decreased,are significant difference(P0.01).Conclusion Treatment of uterine fibroids get good curative effect,10 mg/d group of adverse reactions less than other two groups,the treatment of uterine fibroids more safe and effective.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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