Title: Study on Multiple-resistance of Klebsiella pneumoniae and its aminoglycosides-modifying enzymes gene
Abstract: Objective To study the multiple-resistance of Klebsiella pneumoniae and its aminoglycosides-modifying enzymes gene for the evidence to clinic. Methods Using K-B paper disc test antibiotics sensitivity and screen Klebsiella pneumoniae strains with multiple-resistance. ESBLs and AmpC enzymes were detected with 3-D test. AMEs gene was analyzed by PCR. Results 61 strains of Klebsiella pneumoniae with multiple-resistance showed no resistance to IMP. The resistant rate to aminoglycosides antibiotics was from 60.7% to 100.%, and with 44.3% to 100% of other antibiotics. The detective rates of Klebsiella pneumoniae producing either ESBLs or AmpC enzyme and producing both were 31.1%,14.8% and 45.9% respectively. The positivity of AMEs gene was 86.9%, including aac(3)-Ⅰ, aac(3)-Ⅱ, aac(6')-Ⅰb, aac(6')-Ⅱ, ant(3)-Ⅰ and ant(2)-Ⅰ, were 13.1%, 60.7%, 55.7%, 11.5%, 6.6% or 26.2% respectively. Conclusions The drug-resistance of Klebsiella pneumoniae with high production with ESBLs and AmpC enzymes and high carriage of AMEs gene is serious. Effective antibiotics based on antibiotic-sensitivity is helpful to reduce the spread of Klebsiella pneumoniae strains with antibiotics-resistance.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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