Title: Distribution and drug resistance of 101 strains of Klebsiella pneumoniae
Abstract: Objective To analyze the clinical distribution and drug resistance of nosocomial Klebsiella pneumoniae isolates,and to provide reliable evidence for reducing the infection of Klebsiella pneumoniae.Methods 101 strains of clinical separated Klebsiella pneumoniae from March 2011 to February 2012 were collected and counted in specimens,clinical distribution and 17 kinds of commonly used antimicrobial drugs resistance.Detecting extended spectrum β-lactamase,and using Polymerase Chain Reaction(PCR) detect KPC,IMP,VIM,NDM-1 resistant genes and sequencing.Results Of totally 101 strains of Klebsiella pneumoniae,87 (86.14%) were isolated from sputum.40 (39.60%) were separatedly obtained from Senior Cadre' s and neurology department.The antimicrobial susceptibility testing showed that Klebsiella pneumoniae was most sensitive to imipenem(92.08%),the second was cefotetan (85.15%) and cefepime (80.02%); 70 strains produce extended spectrum β-lactamase, accounting for 69.31%.Among 6 strains of carbapenemase resistant Klebsiella pneumoniae,including 4 strains producing KPC-2 gene,while IPM,VIM and NDM-1 were not found.Conclusions In our hospital,the detection rate of Klebsiella pneumoniae which produced extended spectrum β-lactamase is high.Klebsiella pneumoniae resistant to carbapenem antibiotics may be associated with carrying the KPC-2,and the antibiotics should be used reasonably in order to decrease the drug resistant strains.
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
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