Title: A Randomized Controlled Study Of Treatment-Resistant Schizophrenia With Risperidone And Clozapine Treatment
Abstract: objective To compare the efficacy and safety of risperidone and clozapine in treatment-resistant schizophrenic patients.Method 60 inpatients with treatment-resistant schizophrenia(Kane criteria) were randomly assigned to receive risperidone(n=30) or clozapine(n=30) for 16 weeks.The Positive and Negtive Syndrome Scale(PANSS)、Global Assessment of Function(GAF) and Treatment Emergent Symptoms Scale(TESS) were used to measure therapeutic efficacy and side effects at the baseline and 1,2,4,8,12,16 weeks after treatment.Weshcler Memory Scales(WMS) and Wisconsin Card Sorting Test were used to measure cognitive function before and after the end of treatment.Results Pretreatment PANSS、GAF and TESS scores did not differ between the groups.The PANSS total scores decreased and GAF increased significantly after 8、12、16 weeks treatment in both groups.GAF scores of clozapine group was lower significant than risperidone,and the increasing TESS scores of clozapine group was more significant than risperidone group after the end of treatment. Conclusions Risperidone and clozapine were both effective in treatment-resistant schizophrenic patients.Risperidone could be more tolerate and advantageous to cognition improvement.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot