Title: A Randomized Controlled Trial of Risperidone Combining with Clozapine in Treatment of the Schizophrenic With Long Hospitalization
Abstract: Objective: To investigate the efficacy and safety of risperidone combining with clozapinc in the treatment of the schizophrenic with long hospitalization.Methods: Two hundred schizophrenic who met the criteria for schizophrenic in International Classification of Diseases(ICD-10) were randomly assigned to two groups.One group was treated with risperidone combining with clozapine and the other with risperidone only.The efficacy was measured with the brief psychiatric rating scale(BPRS) and the positive and negative syndrome scale(PANSS).The side effects were assessed with the treatment emergent symptoms scale(TESS).Results: At end point the significant improvement rate in the combining group was higher than that in the risperidone group.In all patients,the BPRS score and PANSS score were decreased after treatment.There were significant differences between the two groups(P0.05).There were no significant differences between the two groups in the TESS score.Conclusion: The therapy of risperidone combing with clozapine has been found to be effective and well-tolerated approach in patients with schizophrenic.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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