Title: Sertraline Combined with Clonazepam in the Treatment of Clomipramine-resistant Obsessive-compulsive Disorders
Abstract: Objective: To study the therapeutic effects of sertraline combined with clonazepam in the treatment of clomipramine-resistant obsessive-compulsive disorders(OCD). Methods:52 patients with OCD resistant to clomipramine were randomly divided into two equal groups. 26 cases in the treatment group were given each 50 mg·d-1 of sertraline PO and 4 mg·d-1 of clonazepam PO in the beginning. 3 days later, the doses of sertraline and chonzepam were increased to 100 mg·d-1 and 8 mg·d-1 PO, respectively. 26 cases in the control group were given sertraline only in a dosage same as that of the treatment group. The course of treatment in both groups lasted 8 weeks. The therapeutic effectiveness was assessed with the Yale-Borwn obsessive-compulsive disorder rating scale(Y-Bocs) and adverse reactions were appraised with the treatment emergent symptom scale(TESS) . Results: The rate of notable effectiveness in the treatment group was 64.5% , while that of the control group, 38.5% . The score of Y-Bocs in the treatment group was significantly lower than that in the control group at the end of the 4th and 8th week( P 0. 05). The difference was insignificant between the adverse reactions of the two groups( P 0.05) . Conclusion: Sertraline combined with clonazepam was shown to be safe and effective in the treatment of clomipramine resistant OCD.
Publication Year: 2003
Publication Date: 2003-01-01
Language: en
Type: article
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