Title: Expressions of matrix metalloprotease-9 and tissue inhibitor of metalloproteinase-1 in kidneys of rats after mechanical injury
Abstract: Objective To investigate the expressions and significance of matrix metalloprotease-9 (MMP-9)and tissue inhibitor of metalloproteinase-1(TIMP-1)in kidneys of rats after mechanical injury.Methods Thirty-six adult female Wistar rats were randomly divided into two groups:6 in control group and 30 in trauma group.The model of trauma rats was constructed by striking the spinal column and ribs of rats with free-falling bio-impactor.MMP-9 and TIMP-1 expressions in renal tissues of each group were detected by tissue chips and immunohistochemistry at 1,6, 12,24 and 36 h after trauma.Results MMP-9 expression of renal tissues was lower in control group while it began to increase at 1 h,reached high peak at 6 h (P0.05)and then dropped gradually to normal in trauma group.TIMP-1 remained relatively unaltered in trauma group. Conclusion MMP-9 may play an important role in kidney injury after mechanical injury.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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