Title: Expression and significance of ribosome protein S15a gene in colorectal carcinoma
Abstract: Objective To study the expression and significance of ribosome protein s15a (RPS15a) gene in colorectal carcinoma tissues. Methods SP immunohistochemistry was used to detect the expression of RPS15a protein in 82 samples of colorectal carcinomaand adjacent nonneoplastic tissues. Results In the 82 samples of colorectal carcinoma and adjacent normal tissues, the positive expression rate of RPS15a protein was 72.0% (59/82) and 40.2% (33/82), respectively. Statistical analysis suggested that the positive expression rate of RPS15a protein in the colorectal carcinoma tissues was significantly higher than that in the normal tissues (χ2=17.76, P 0.05). The expression of RPS15a protein was significantly correlated with the depth of invasion (χ2=5.47, P 0.05) and lymph node metastases (χ2=5.89, P 0.05). Conclusion High expression of RPS15a protein may play an important role in the development of colorectal carcinoma tissues.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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