Title: Relationship between the Expression of PTEN mRNA and Protein in Colorectal Carcinoma
Abstract: Objective: To investigate the relationship between PTEN expression and the carcinogenesis of colorectal mucosa,invasion and metastasis of colorectal carcinoma.Method: The mRNA and protein expressions of PTEN were evaluated by reverse transcription polymerase chain reaction(RT-PCR) and Western blot in 75 cases of colorectal carcinomas and the adjacent normal mucosa.Result: The positive rates of PTEN mRNA expression were 93.3%,75.0 and 47.6% in adjacent normal mucosa,early and advanced colorectal carcinoma,respectively.The positive rates of PTEN protein expression were 96.0%,66.7% and 49.2% in corresponding tissues.PTEN mRNA and protein expression was significantly correlated with cell differentiation(P0.05),tumor Dukes stage and lymph node metastasis of colorectal carcinomas(P0.05).Significant difference in PTEN mRNA expression was found between early colorectal carcinoma and advanced colorectal carcinoma(P0.05).The expression of PTEN mRNA was positively associated with that of PTEN protein(r=0.99,P0.01).Conclusion: Decreased expressions of PTEN mRNA and protein were significantly correlated with carcinogenesis and progression of the colorectal carcinoma.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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