Title: Relationships between VEGF,MMP-7 and Biological Behaviors in Colorectal Carcinoma
Abstract: Objective To explore the relationships between VEGF,MMP-7 expression and progress,prognosis of colorectal Carcinoma.Methods SP immunohistochemical staining was used to examine expressions of VEGF,MMP-7 among 81 cases of colorectal carcinoma paraffin-embedded specimens.Rank sum test was used to analyze the expressions of VEGF,MMP-7.Results The expression of VEGF in colorectal carcinoma was positively correlated with depth of invasion(P0.01),lymph node metastasis(P0.01),distant metastasis(P0.01),Dukes stage.MMP-7 expression in colorectal carcinoma was also positively correlated with lymph node metastasis(P0.05),distant metastasis(P0.01),Dukes' stage.Expression of MMP-7 in mucous group was higher than that in high differentiation group(P0.01).The MMP-7 expression in patients aged below 60y was stronger than that in over 60y and 60y(P0.05).Positive relationship appeared between VEGE and MMP-7.Conclusion VEGF,MMP-7 may improve the growth and metastasis of colorectal carcinoma.They could be prognostic factor of colorectal carcinoma.Decreasing the expression and activity of VEGF and MMP-7 might be a new pathway for the treatment of colorectal carcinoma.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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