Title: Myocardial Protection of Ulinastatin in Patients undergoing Coronary Artery bypass Grafting with Cardiopulmonary Bypass
Abstract: Objective To observe the protective effects of ulinastatin(UTI)on myocardium during coronary artery bypass grafting(CABG)with cardiopulmonary bypass(CPB).Methods 60 patients scheduled for CABG with CPB were randomly divided into control group(group C)and ulinastatin group(group U),30 in each.In group U,the patients received UTI 1 000 000 U in all,300 000 U in which was given intravenously before anesthesia and 400 000 U was added into the primary solution,the last 300 000 U was given after declamping aorta.Control group(group C)did not receive UTI intravenously or in the priming.Plasma levels of CK,CK-MB and cTnI were measured before induction(t1),30 min following clamping(t2),reperfusion l h(t3),reperfusion 6 h(t4)and reperfusion24 h(t5).Results The plasma level of CK,CK-MB and cTnI increased significantly at t3,t4 and t5 in both groups compared with those at t1(P0.05).The plasma cTnI level of group C at t3,t4 and t5 was significantly higher than that of group U(P0.05),and the plasma CK and CK-MB level of group C at t4,t5 was significantly higher than that of group U(P0.05),respectively.Conclusion Ulinastatin can effectively protect myocardium from ischemia-reperfusion injury during CPB.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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Cited By Count: 1
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