Title: Effects of sevoflurane wash-in during cardiopulmonary bypass on inflammatory responses in patients undergoing coronary artery bypass grafting
Abstract: Objective To investigate the effects of sevoflurane wash-in during cardiopulmonary bypass (CPB) on inflammatory responses in patients undergoing coronary artery bypass grafting (CABG).Methods Forty ASA physical status Ⅱ or Ⅲ patients,aged 45-60 yr,weighing 53-89 kg,scheduled for elective CABG under CPB,were randomly divided into 2 groups (n =20 each) using a random number table:control group (group C) and sevoflurane group (group S).Sevoflurane 1%-2% was washed into the extracorpomal circuit during CPB in group S.Blood samples were taken from the central vein at 5 min after induction of anesthesia and 4,12 and 24 h after termination of CPB for determination of the concentration of plasma cardiac troponin Ⅰ (cTnI).Myocardial specimens were obtained from the right auricle at the end of CPB for determination of IL-Iβ and IL-6 expression by immuno-histochemistry.Results Compared with group C,the plasma concentration of cTnI was significantly decreased,and IL-1β and IL-6 expression in myocardial tissues was down-regulated in group S (P < 0.05).Conclusion The mechanism by which sevoflurane wash-in during CPB attenuates myocardial injury is related to inhibition of inflammatory responses in patients undergoing CABG.
Key words:
Anesthetics, inhalation ; Cardiopulmonary bypass; Inflammation ; Myocardial ; Coronary artery bypass
Publication Year: 2013
Publication Date: 2013-10-20
Language: en
Type: article
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Cited By Count: 1
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