Title: Effect of angiotensin II and transforming growth factor-β_1 in asthmatic rats and the influence of angiotensin II receptor antagonist
Abstract: [Objective] To study the effect of angiotensinⅡ(AngⅡ)、transforming growth factor-β1(TGF-β1)on the development of asthmatic rats,and the influence of angiotensin Ⅱ receptor antagonist(AT1).[Methods] 40 rats were randomly divided into five groups:(A)control group,(B)challenged by OVA for 3 days,(C)challenged by OVA for 2 weeks,(D)challenged by OVA for 4 weeks,(E)using AT1 after challenged by OVA for 4weeks,and each group contains 8 rats.Study the pathologic changing of airway;the expression and significance of AngⅡ and TGF-β1 and the influence of AT1 by immunohistochemical staining.[Results] The airway became fibrotic with challenged by OVA as time prolong;the intervention of AT1 could improve the fibrotic change.The expression of AngⅡ and TGF-β1 became higer and higher with the challenged time prolong;the C and D groups had significant difference compared with control group(P0.05);the expression of AngⅡ and TGF-β1 in E group drops significantly compared with those of group D(P0.05).[Conclusion] ① the expression of AngⅡ and TGF-β1 AngⅡ gradually increase with the development of airway remodeling,which indicate they can contribuate to airway remodeling of asthmatic rats.② AT1 can improve airway remodeling via reducing the expression of AngⅡ and TGF-β1 and preventing the fibrotic changes of airway tissue.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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