Publication Information

{'id': 'https://openalex.org/W2370079394', 'doi': None, 'title': 'Overexpression of α-synuclein in SH-SY5Y cells in vitro leads to oxidative stress', 'display_name': 'Overexpression of α-synuclein in SH-SY5Y cells in vitro leads to oxidative stress', 'publication_year': 2005, 'publication_date': '2005-01-01', 'ids': {'openalex': 'https://openalex.org/W2370079394', 'mag': '2370079394'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://en.cnki.com.cn/Article_en/CJFDTOTAL-ZBLS200508018.htm', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2765062696', 'display_name': 'Zhongguo bingli shengli zazhi', 'issn_l': '1000-4718', 'issn': ['1000-4718'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4320800525', 'host_organization_name': 'Chinese Medical Association', 'host_organization_lineage': ['https://openalex.org/P4320800525'], 'host_organization_lineage_names': ['Chinese Medical Association'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': [], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5110684884', 'display_name': 'Yuxin Zhang', 'orcid': 'https://orcid.org/0000-0003-0794-7646'}, 'institutions': [], 'countries': [], 'is_corresponding': True, 'raw_author_name': 'Zhang Yu-xin', 'raw_affiliation_strings': ['~1, ZHANG Zi-ming~1, YANG Hui~2, CAI Qing~2, LU Qiang~2, CHEN Biao~2, XU Qun-yuan~2'], 'affiliations': [{'raw_affiliation_string': '~1, ZHANG Zi-ming~1, YANG Hui~2, CAI Qing~2, LU Qiang~2, CHEN Biao~2, XU Qun-yuan~2', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 0, 'institutions_distinct_count': 0, 'corresponding_author_ids': ['https://openalex.org/A5110684884'], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.214, 'has_fulltext': False, 'cited_by_count': 2, 'citation_normalized_percentile': {'value': 0.549105, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 68, 'max': 71}, 'biblio': {'volume': None, 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10085', 'display_name': "Parkinson's Disease Mechanisms and Treatments", 'score': 0.9843, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10085', 'display_name': "Parkinson's Disease Mechanisms and Treatments", 'score': 0.9843, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13991', 'display_name': 'Nuclear Receptors and Signaling', 'score': 0.963, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/dichlorofluorescein', 'display_name': 'Dichlorofluorescein', 'score': 0.8542752}, {'id': 'https://openalex.org/keywords/sh-sy5y', 'display_name': 'SH-SY5Y', 'score': 0.75780696}, {'id': 'https://openalex.org/keywords/lipofectamine', 'display_name': 'Lipofectamine', 'score': 0.5002723}], 'concepts': [{'id': 'https://openalex.org/C2779964046', 'wikidata': 'https://www.wikidata.org/wiki/Q209286', 'display_name': 'Dichlorofluorescein', 'level': 3, 'score': 0.8542752}, {'id': 'https://openalex.org/C2776151105', 'wikidata': 'https://www.wikidata.org/wiki/Q898814', 'display_name': 'Oxidative stress', 'level': 2, 'score': 0.78895676}, {'id': 'https://openalex.org/C79879829', 'wikidata': 'https://www.wikidata.org/wiki/Q5571762', 'display_name': 'Intracellular', 'level': 2, 'score': 0.772717}, {'id': 'https://openalex.org/C2779083432', 'wikidata': 'https://www.wikidata.org/wiki/Q7390126', 'display_name': 'SH-SY5Y', 'level': 4, 'score': 0.75780696}, {'id': 'https://openalex.org/C54009773', 'wikidata': 'https://www.wikidata.org/wiki/Q1429031', 'display_name': 'Transfection', 'level': 3, 'score': 0.74812394}, {'id': 'https://openalex.org/C538909803', 'wikidata': 'https://www.wikidata.org/wiki/Q116907', 'display_name': 'Glutathione', 'level': 3, 'score': 0.70471036}, {'id': 'https://openalex.org/C48349386', 'wikidata': 'https://www.wikidata.org/wiki/Q424361', 'display_name': 'Reactive oxygen species', 'level': 2, 'score': 0.64459836}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.537228}, {'id': 'https://openalex.org/C49923114', 'wikidata': 'https://www.wikidata.org/wiki/Q17139621', 'display_name': 'Lipofectamine', 'level': 5, 'score': 0.5002723}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.40429223}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.39898306}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.32830942}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.31975293}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.29854113}, {'id': 'https://openalex.org/C40767141', 'wikidata': 'https://www.wikidata.org/wiki/Q285697', 'display_name': 'Recombinant DNA', 'level': 3, 'score': 0.0852063}, {'id': 'https://openalex.org/C2776715637', 'wikidata': 'https://www.wikidata.org/wiki/Q938205', 'display_name': 'Neuroblastoma', 'level': 3, 'score': 0.08355498}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.08289862}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.06898481}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C92087593', 'wikidata': 'https://www.wikidata.org/wiki/Q427389', 'display_name': 'Vector (molecular biology)', 'level': 4, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://en.cnki.com.cn/Article_en/CJFDTOTAL-ZBLS200508018.htm', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2765062696', 'display_name': 'Zhongguo bingli shengli zazhi', 'issn_l': '1000-4718', 'issn': ['1000-4718'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4320800525', 'host_organization_name': 'Chinese Medical Association', 'host_organization_lineage': ['https://openalex.org/P4320800525'], 'host_organization_lineage_names': ['Chinese Medical Association'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3031023273', 'https://openalex.org/W2984851223', 'https://openalex.org/W2904038656', 'https://openalex.org/W2392224009', 'https://openalex.org/W2386159846', 'https://openalex.org/W2377541919', 'https://openalex.org/W2374560192', 'https://openalex.org/W2370914118', 'https://openalex.org/W2370451369', 'https://openalex.org/W2368778207', 'https://openalex.org/W2363126818', 'https://openalex.org/W2351737822', 'https://openalex.org/W2325636087', 'https://openalex.org/W2252670783', 'https://openalex.org/W2172079964', 'https://openalex.org/W2123207666', 'https://openalex.org/W2102884977', 'https://openalex.org/W1984960879', 'https://openalex.org/W1932331334', 'https://openalex.org/W1037500466'], 'abstract_inverted_index': {'AIM:': [0], 'To': [1], 'observe': [2], 'the': [3, 10, 81, 90, 98, 125, 133], 'influence': [4], 'of': [5, 7, 17, 28, 59, 83, 93, 109, 135], 'overexpression': [6], 'α-synuclein': [8, 29, 72, 110, 126], 'on': [9], 'cultured': [11, 76], 'SH-SY5Y': [12, 22, 77, 112], 'cells.': [13], 'METHODS:': [14], 'The': [15, 26, 35, 56, 71, 85], 'plasmid': [16, 82], 'α-synuclein-pcDNA_3': [18], 'was': [19, 30, 40, 62, 73], 'transfected': [20, 79, 99], 'into': [21], 'cells': [23, 78, 100, 113], 'with': [24, 42, 64, 80], 'LipofectAMINE.': [25], 'expression': [27], 'determined': [31, 41], 'by': [32, 47, 68], 'anti-α-synuclein': [33], 'immunocytochemistry.': [34], 'intracellular': [36, 57, 91, 115], 'reactive': [37, 116], 'oxygen': [38, 117], 'species': [39, 118], "2',": [43], "7'-dichlorofluorescein": [44], 'diacetate': [45], '(DCF-DA)': [46], 'using': [48], 'a': [49], 'FACSCAN': [50], 'flow': [51], 'cytometer': [52], 'and': [53, 89, 107], 'fluorescent': [54], 'microscope.': [55], 'content': [58], 'reduced': [60, 94], 'GSH': [61, 95], 'detected': [63], 'glutathione': [65], 'assay': [66], 'kit': [67], 'spectrophotometer.': [69], 'RESULTS:': [70], 'expressed': [74], 'in': [75, 111, 132], 'α-synuclein-pcDNA_3.': [84], 'DCF': [86], 'loading': [87], 'analysis': [88], 'level': [92], 'suggested': [96, 122], 'that': [97, 124], 'were': [101], 'under': [102], 'oxidative': [103], 'stress.': [104], 'CONCLUSION:': [105], 'Overexpression': [106], 'accumulation': [108], 'increase': [114], 'levels,': [119], 'it': [120], 'is': [121], 'therefore': [123], 'does': [127], 'play': [128], 'an': [129], 'important': [130], 'role': [131], 'pathogenesis': [134], "Parkinson's": [136], 'disease.': [137]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2370079394', 'counts_by_year': [], 'updated_date': '2024-12-24T12:34:24.872090', 'created_date': '2016-06-24'}