Title: The Effect of Expression of KAI1 Gene on the Metastasis of Colorectal Carcinoma
Abstract: Objective To investigate the correlation between KAI1 gene expression and metastatic behavior in human colorectal carcinoma. Methods KAI1mRNA expression was examined in 45 colorectal primary carcinomas,4 liver metastases,10 lymph node metastases by self- quantitative reverse transciption- polymenase chain reaction, 45 normal colonic mucosa tissue samples served as control group. Results KAI1 expression was higher in primary carcinomas than in normal mucosa( 40/45,P 0.01) ,and was inversely correlated with Dukes’stage( P 0.01) and lymph node metastasis( P 0.01) . KAI1 expression was lower in Dukes’C and Dukes’D than in Dukes’B ( P 0.05) , and lower in lymph node metastases ( P 0.01) . KAI1 expression was significantly different in primary colonic tumors in the presence and absence of lymph node metastasis. Conclusion The expression of KAI1 is inversely correlated with lymph node involvement, Dukes’stage. The down- regulation of KAI1 gene is associated with lymph node metastasis of colorectal carcinoma.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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