Title: Expression and significance of CCR7 and L-selectin in human colorectal carcinoma tissue
Abstract: Objective To investigate the expression of chemokine receptor 7(CCR7)and adhesion molecule L-selectin in human colorectal carcinoma,and analyze their correlation with lymph node metastasis.Methods The expression of CCR7 and L-selectin were tested by immunohistochemical method in 63 cases of colorectal carcinoma specimens(colorectal carcinoma group),44 cases of normal intestinal mucosa adjacent to carcinoma(adjacent group) and 31 cases of metastatic tumor tissue(metastasis group).Results The positive rate of CCR7 and L-selectin expression in the colorectal carcinoma group and metastatic tumor tissue were significantly higher than that in adjacent group and metastasis group(P0.01);There was significantly positive dependability between expression of CCR7 and L-selectin(r=0.653,P0.01).The expression in the tissue with lymph node metastasis was significantly higher than that in the tissue without lymph node metastasis(P0.05).Conclusions The expression of CCR7 and L-selectin are closely associated with development and metastasis of the colorectal carcinoma.CCR7 and L-selectin maybe participate together in the carcinogenesis and lymph node metastasis of colorectal carcinoma.Detection of the two marker conduces to judge the patient's prognosis.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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Cited By Count: 1
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