Title: THE RELATIONSHIP BETWEEN TGF-β_1 EXPRESSION IN AIRWAY SMOOTH MUSCLE AND AIRWAY REMODELING IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE
Abstract: Objective To study the role of TGF-β1 expression in airway remodeling in chronic obstructive pulmonary di-sease(COPD).Methods Lung specimens from 15 male patients without COPD(non-COPD group),and 15 male COPD patients with lung cancer(COPD group) were investigated.Remodeling of airway was observed under a light microscope,and the changes of morphology were analyzed by image processing system.The expression of TGF-β1 in bronchial smooth muscle cells were observed by immunohistochemical method.Results In COPD group: the WT% and WA% were higher than that in non-COPD group,respectively,the differences being significant(t=10.93,15.35;P0.01);the TGF-β1 expression was higher than that in non-COPD group(t=17.67,P0.01).FEV1.0% was negatively correlated with WT%,WA%,and TGF-β1(r=-0.787,-0.899,-0.846;P0.01);TGF-β1 was positively correlated with WT% and WA%(r=0.837,0.915;P0.01).ConclusionIrregular small airway smooth muscle proliferation and extracellular matrix deposition are the main pathological features of airway remodeling;TGF-β1 plays an important role in the pathogenesis of COPD.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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