Title: EFFECTS OF HAWTHORN LEAVES FLAVONOIDS PRETREATMENT ON ANTIOXIDASE IN BRAIN OF CEREBRAL ISCHEMIA REPERFUSION MICE
Abstract: Objective: To investigate the effects of Hawthorn Leaves Flavonoids (HLF) pretreatment on antioxidiase activity in brain of local cerebral is chemia reperfusion mice.Methods:80 kunming mice were applied in this study and divided into the following groups at random: sham-operation group, ischemia reperfusion model group and HLF low, middle, high dose group. The local cerebral ischemia reperfusion model was made by suture method.The mice in 3 HLF groups were given different dose of HLF(20,40,60g/kg)l week before operation. The MDA content and LDH, SOD activity in brain were measured respectively .Results: HLF low, middle and high dose could obviously increase the LDH, SOD activity in brain of local cerebral ischemia reperfusion mice (P0.05, P0.01); HLF middle and high dose could significantly decrease the MDA content (P0.05, P0.01).Conclusions:HLF pretreatment could protect the brain of local cerebral ischemia reperfusion mice, its mechanism may relate to its antioxygen effects.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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