Title: Expression and Clinical Significance of LIVIN and HLA-I in the Clear Cell Renal cell Carcinomas
Abstract: Objective: To study the expression and clinical significance of Livin and HLA-I in clear cell renal cell carcinoma(ccRCC).Methods: 80 patients who underwent radical nephrectomy from December 2007 to December 2011 in the First Affiliated Hospital of Harbin Medical University were selected. Immunohistochemical staining was used to determine the expression of Livin and HLA-I in 80 cases of ccRCC tissues and 10 cases of normal renal tissues, and analyze its relationship with clinicopathological features of patients. Results: The positive rate of Livin was 0 % while HLA-I was expressed in all normal renal tissues. Livin was expressed in 41(51.25 %) of80 renal cancer tissues, and the expression of HLA-I was down-regulated in 48(60.00 %)specimens. The expression of Livin in ccRCC was associated with the metastasis and the degree of tissue differentiation, but the expression of HLA-I had no correlation with age, sex,TNM stage or Lymphatic metastasis. The expression of Livin was not correlated with that of HLA-I in ccRCC. Conclusion: Livin and HLA-I may play an important role in the occurrence and progression of ccRCC, Livin may be important diagnostic/therapeutic indicator or target in ccRCC.
Publication Year: 2014
Publication Date: 2014-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot