Title: Prognostic value of plasma D-dimer for non-small-cell lung cancer
Abstract: Objective To evaluate the prognostic value of plasma D-dimer for non-small-cell lung cancer( NSCLC). Methods The clinical data from 77 NSCLC patients and 98 healthy controls were retrospectively analyzed. The patients' clinical and laboratory information including the baseline and postoperative 9thday plasma D-dimer levels,tumor stage and differentiation grade were extracted. The correlation between preoperative plasma D-dimer level and clinical characteristics of NLCLC was analyzed. The relationship between baseline plasma D-dimer level and the fatality was analyzed by Kaplan-Meier survive curve. Results The plasma D-dimer level before operation in NSCLC patients was significantly higher than that on the 9thday after operation and that in healthy controls( t = 4. 350,P 0. 01). The baseline plasma D-dimer level in NSCLC patients increased with the advance of tumor grade( t = 9. 294,P 0. 01),but was not related to the differentiation grade of NSCLC( F = 0. 532,P = 0. 53). The fatality of NSCLC patients with plasma D-dimer level ≤ 0. 87 mg / L was significant lower than that with plasma D-dimer level 0. 87 mg / L( χ2= 9. 72,P 0. 01). Conclusion Plasma D-dimer is a useful marker to estimate the prognosis of NSCLC.
Publication Year: 2014
Publication Date: 2014-01-01
Language: en
Type: article
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