Title: Expression of GLUT1 and VEGFR-3 in human laryngeal squamous cell carcinoma and their relationship with lymphatic metastasis
Abstract: Objective To investigate the expression of glucose transporter 1(GIUT1) and vascular endothelial cell growth factor receptor 3(VEGFR-3) in human laryngeal squamous cell carcinoma and their relationship with lymphatic metastasis.Methods The expression of GLUT1 and VEGFR-3 in tumor tissues,peritumoral tissues and normal tissues from 57 patients with human laryngeal squamous cell carcinoma analyzed was detected by immunohistochemistry method with clinicopathological features of the patients.Results The expression of GLUT1 and VEGFR-3 was significantly higher in tumor tissues than in peritumoral tissues and normal tissues(P 0.01).The expression of GLUT1 and VEGFR-3 was significantly correlated with lymphatic metastasis(P = 0.012).Conclusion GLUT1 and VEGFR-3 play an important role in tumorigenesis,development,lymphatic metastasis and prognosis of human laryngeal squamous cell carcinoma,which can be used as one of the indicators for diagnosis,treatment and prognosis.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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